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At a Glance

Up to 6 weeks
Accredited
Part Time
CPPD (15 credits)
Blended learning

Disease Modelling and Genome Engineering

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This course provides essential knowledge about the use of model systems to investigate the functional genomics of inherited human diseases, an overview of genomic engineering technologies and a workshop for the design of CRISPR-Cas9 reagents.

This module forms part of the HEE Genomics Education Programme’s Master’s in Genomic Medicine framework. It is offered by the course provider in addition to the framework’s core and optional modules.

Description

During this course, you will explore examples of engineered models, enabling you to study human disease and to understand the merits and drawbacks of many of the cell and animal models available to researchers. There will also be opportunities to discuss the ethics of using animal models and the potential of genomic engineering to alter human genomes.

Learn from leading experts in genomics about:

  • Why animal and cellular models are necessary for studying the functional genomics of human disease.
  • The different model systems available for studying human disease.
  • How to manipulate gene expression in a variety of model systems.
  • The genome engineering techniques available, how to design associated reagents, and how to use them.
  • The ethical considerations associated with animal models and genome engineering.
  • How to use literature and online resources to access information on disease modelling and genomic engineering.
  • How to apply knowledge of model systems and genome engineering to critically analyse published data and to design experiments.

Learning outcomes

By the end of this module you will be able to:

  • Use advanced knowledge in how to manipulate the genomic sequence and gene expression of cell and animal models to evaluate models of human disease.
  • Use advanced knowledge in how to manipulate the genomic sequence and gene expression of cells, animals and humans to evaluate therapeutic treatments for inherited human disease.
  • Describe and critically evaluate a range of contemporary genomic technologies to alter the sequence and expression of genes.
  • Debate the ethical arguments about the use of animal models to study human disease and the ethical concerns about being able to alter genomes in vitro and in vivo.
  • Critically evaluate the methods and technologies used to generate model systems of inherited human diseases.
  • Critically evaluate the methods and technologies used to generate therapies employing altered gene expression for the treatment of inherited human diseases.
  • Review and critically analyse the scientific literature relevant to model systems and genomic engineering pertinent to inherited human disease.
  • Present a case from the literature on a model system, or treatment, of an inherited human disease.
  • Use web-based tools to design regents to alter the expression of genes or genomic sequence.

Funding rules

Funding covers course fees only and is limited to NHS healthcare professionals working in England on a permanent contract from the full range of professional backgrounds and groups (such as medicine, nursing, healthcare scientists and technologists).  Please note funding can only be allocated to those who are post registration professionals.

University entry requirements may include criteria around existing understanding and minimum English language requirements.

The Genomics Education Programme provides limited funding to the Universities listed below. Please check with your preferred university to obtain details of the programme modules and entry criteria. See below for the key steps in the application process:

Click here to view the application process for CPPD module(s) or postgraduate certificate

Click here to view the application process for extending a PGcert to a PGdip, or a PGdip to a Master’s degree

Timetable

Start date
 University of Manchester TBC

Please check your preferred university’s website for more detailed information about start dates, length and mode of study.

FAQs

Are applications for funding still open during the Covid-19 pandemic?

Yes. Many of our partner universities are running modules online and funding is available. Please contact your chosen university to discuss your options. You must meet the Health Education England Genomics Education Programme eligibility criteria to receive funding for modules.

I have previously applied and received funding for two modules, but would like to complete two more. Is it possible to transfer my studies to another university?

Yes.  You will need to speak to your chosen university re your requirements. You must also meet the HEE GEP eligibility criteria for funding.

I have previously applied and received funding for two modules, but would like to complete two more. Is it possible to obtain funding?

Yes.  You will need to speak to your chosen university re your requirements. You must also meet the HEE GEP eligibility criteria for funding

I have been awarded funding and started the programme, but I am unable to complete. What are my options?

Funding is awarded for the period specified in the application form and there is no automatic ability to defer completion of the programme. You should speak to your university in the first instance about your situation and also contact the Genomics Education Programme (GEP) team regarding funding.

You may choose to reduce the workload of your programme by switching from, for example, a full Master’s degree to a diploma or certificate. Again, you would need to contact your course provider and the GEP.

How much study time is required to undertake this programme?

Study time will vary across the course providers. You are advised to visit your preferred university’s website for more information or to contact the relevant course lead. Most modules involve around 5 days of face-to-face teaching, followed by 2-4 weeks of independent study and assessment preparation. However, distance learning options are available for most universities.

 

Can I build up my CPPD modules to a full Master’s, PGDip or PGCert qualification?

Funding is allocated on an individual module basis only. Candidates who meet the HEE Genomics Education Programme eligibility criteria for funding can apply for up to four funded modules in the first instance. If you wish to progress to a full Master’s or PGDip, you should discuss options with your chosen university.

I am eligible but have been refused a commissioned place – why?

This may be due to the following potential reasons:

  • The university you have applied to has used up all its commissioned allocations.
  • The total number of available national commissions have been fully allocated.
  • We are now applying controls to the commissioned places based on healthcare profession roles to help ensure equitable access across professions on a national scale.

I am not eligible for a HEE-funded place – can I self-fund?

This should be discussed with your preferred university.

I work for an organisation that provides services to the NHS – am I eligible to apply?

Yes – please provide details of your organisation and its services for the NHS when you apply to your preferred university.

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University Providers

Funded

The logos below indicate the university providers that are able to accept HEE funded applications for this course. Follow the links provided to begin your university application process.

University of Manchester

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