Marfan syndrome
Marfan syndrome is one of the most common inherited connective tissue conditions, with an estimated prevalence of approximately 1 in 5,000. It is an autosomal dominant condition resulting from disease-causing (pathogenic or likely pathogenic) variants in the fibrillin 1 gene (FBN1). Untreated Marfan syndrome is associated with a significant risk of morbidity and mortality, but appropriate surveillance and management can result in a normal life expectancy.
Clinical features
Marfan syndrome is a complex multi-systemic condition. The cardinal features are cardiovascular, skeletal and ocular disease, but there is significant variability and not all affected individuals will have the full range of features.
Cardiovascular disease
Pathology of the aortic root, leading to dilatation, regurgitation and dissection, is the main cause of morbidity and mortality in Marfan syndrome. Importantly, severity of cardiovascular manifestations exhibit poor correlation with ocular or skeletal manifestations. Rarely, sudden cardiac death can be the first presentation of the condition. Echocardiography and CT or MRI should be used regularly to assess and monitor the aorta. Mitral valve prolapse is a common feature.
Skeletal manifestations
Individuals with Marfan syndrome are often taller than their predicted height, with disproportionately long limbs resulting in an increased arm span (height ratio >1.05). Arachnodactyly (long, slender fingers) is typically present. Other skeletal and skin findings include pectus malformations, scoliosis and/or kyphosis, reduced elbow extension, excessive skin striae and hindfoot malformation or pes planus. Generalised joint hypermobility may occur, resulting in features that overlap with other connective tissue conditions such as the more common (and benign) joint hypermobility syndromes.
Ocular findings
Ectopia lentis (lens dislocation) is the most specific ocular pathology associated with Marfan syndrome. Other ocular features include myopia (short-sightedness), glaucoma, cataracts and atraumatic retinal detachment.
Other features
Patients with Marfan syndrome can be predisposed to spontaneous pneumothorax. Recurrent herniae, joint hypermobility, dental crowding and a high, arched palate may occur, but it should be noted that these features are considered non-specific for Marfan syndrome. Dural ectasia (the widening of the dural sac surrounding the spinal cord) usually occurs in the lumbosacral region and can cause chronic back pain.
Genetics
Most patients with Marfan syndrome have a pathogenic or likely pathogenic variant in the FBN1 gene, which encodes the connective tissue protein fibrillin 1.
Inheritance and genomic counselling
Marfan syndrome is an autosomal dominant condition, which means that affected individuals have a 50% chance of passing the condition on to each of their children. However, the severity of the condition may vary between individuals in the same family.
In total, 25% of disease-causing variants occur de novo (they occur spontaneously in the individual for the first time, rather than being inherited). If the FBN1 variant appears de novo, there is a small possibility of two unaffected parents having a second affected child due to constitutional (germline) mosaicism.
Individuals with a Marfan diagnosis should be referred to clinical genetics to discuss the family implications, cascade predictive testing and reproductive options if appropriate. As there are screening and management options, children should also be referred to discuss predictive testing.
Management
The diagnosis of Marfan syndrome is most commonly made using the 2010 revised Ghent criteria. These are based on the presence or absence of family history, physical examination findings, aortic root measurements and results of genomic testing (if appropriate). Genomic testing should be considered following assessment by a clinical geneticist or a clinician with expertise in aortopathies.
At diagnosis, a baseline ophthalmic examination, echocardiogram and CT or MRI of the aorta should be performed. Monitoring of the aorta following the baseline assessment should be repeated at regular intervals (as dictated by aortic measurements – usually yearly).
Beta blockers and angiotensin II receptor blockers (ARBs) may reduce progression of aortic dilatation in Marfan syndrome and should be considered in all patients, including children. Elective aortic root replacement surgery should also be considered, depending on aortic root measurements and other risk factors.
Patients with Marfan syndrome should be advised to avoid activities that significantly increase the risk of aortic dissection (particularly contact sports and isometric exercise), and patients considering competitive sport should discuss it with a specialist.
Patients with Marfan syndrome who are pregnant or considering pregnancy should have preconceptual counselling. They should be advised regarding cardiovascular risk, teratogenic medications (such as ACE inhibitors, warfarin and ARBS) and alternatives, as well as the option of preimplantation genetic testing where relevant. These options all require close monitoring in a specialist maternal cardiac service during pregnancy and the post-partum period.
Resources
For clinicians
- NHS England: National Genomic Test Directory
- The Marfan Foundation: Calculation of systemic score
References:
- Erbel R, Aboyans V, Boileau C and others. ‘2014 ESC guidelines on the diagnosis and treatment of aortic diseases: Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult‘. European Heart Journal 2014: volume 35, issue 41, pages 2,873–2,926. DOI: 10.1093/eurheartj/ehu281
- Isselbacher EM, Preventza O, Hamilton Black J and others. ‘2022 ACC/AHA guideline for the diagnosis and management of aortic disease: A report of the American Heart Association/American College of Cardiology joint committee on clinical practice guidelines‘. Circulation 2022: volume 146, issue 24, pages 334–482. DOI: 10.1161/CIR.0000000000001106
For patients
- NHS Health A to Z: Marfan syndrome
- The Marfan Foundation