Definition
A pattern of inheritance for a genetic condition that occurs when a copy of a gene located on the X chromosome has a genetic variant.
Use in clinical context
X-linked inheritance patterns differ depending on the type of inheritance. Recessive X linked conditions are always passed through the maternal line with the condition appearing in males and being carried in females, but not usually expressed. Dominant X-linked conditions can be passed from either affected parent to their children. If the father has the affected copy of the gene he will only pass the condition to his daughters and not his sons. Mothers can pass X-linked dominant conditions to both their sons and daughters. Examples of X-linked conditions include Haemophilia and Duchenne muscular dystrophy.
Related terms
Chromosome | Dominant allele | Recessive allele | Sex chromosome
